Assessing advances in three decades of clinical antiretroviral therapy on the HIV-1 reservoir.

A decreasing trend in the population’s viral reservoir size following initiation of treatment has been observed since 2007.

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Given that a large part of the reservoir in PWH receiving ART is established at initiation of treatment ( 18 ), the interruption of the integration step by InSTIs is clearly significant, differentiating this family from other antiretroviral drugs, with wide-ranging implications for the viral reservoir, particularly in terms of its size, even years after initiation of ART ( 19 ).

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