Microglial NLRP3-gasdermin D activation impairs blood-brain barrier integrity through interleukin-1β-independent neutrophil chemotaxis upon peripheral inflammation in mice.

Consistently, IL-1RA did not block peripheral LPS-induced myeloid cell infiltration into the brain, while MCC950 exhibited notable protection that did not reach statistical significance (Fig. 3d–f ; Supplementary Fig. 7a, b ).

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