Quantitative peripheral live single T-cell dynamic polyfunctionality profiling predicts lung cancer checkpoint immunotherapy treatment response and clinical outcomes.

Transl Lung Cancer Res · 2024 · PMC11736609 · PMID 39830778

Europe PMC DOI

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closest p · 1.4× alpha

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a strong trendP=0.07so close (0.05 < p ≤ 0.1)

Interestingly, high CD4 + T-cells ΔPSI >5 was found to correlate with a strong trend of improved progression-free survival (3.9-fold) (10.8 vs. 2.8 months; P=0.07) and overall survival (3-fold) (34.5 vs. 11.5 months; P=0.09) in ICI-treated patients.

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