A limited but highly significant up-regulated gene response overlapped with our human nose organoid line, a complex pseudostratified ciliated epithelium, suggesting that the gene expression profile detected in SARS-CoV-2 infected adults is generated from both the epithelial and cellular immune responses.
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Longitudinal host transcriptional responses to SARS-CoV-2 infection in adults with extremely high viral load.
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The sentences
Even in instances of nominally significant genes only moderately exceeding chance expectations by FDR, the nominally significant genes were found in downstream enrichment analyses (involving functional gene sets and results of external SARS-CoV-2-related RNA-seq datasets) to contain biological information.