Factors Associated With the Absence of Cervical Spine Instability in Rheumatoid Arthritis: A >10-Year Prospective Multicenter Cohort Study.

In patients without instability, no administration of biological agents was also common, with marginal significance (p=0.070), suggesting its potential as a >10-year predictor for the absence of instability ( Table 2 ).

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Finally, a backward stepwise multivariable logistic regression model, also with sufficient predictive ability, disclosed Steinbrocker stages I–II (OR, 5.355; 95% CI, 1.652– 17.352; p=0.005) and no corticosteroids (OR, 3.868; 95% CI, 1.387–10.789; p=0.010) as key predictive factors for no de novo development of cervical spine instability, although CRP level ≤1.0 mg/dL did not reach statistical significance (OR, 2.453; 95% CI, 0.915–6.576; p=0.075) ( Table 5 ).

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