Sir2 and Fun30 regulate ribosomal DNA replication timing via MCM helicase positioning and nucleosome occupancy.

Deletion of FUN30 in a SIR2 background also showed a trend of increased origin activation, though this difference was not statistically significant.

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The p-value obtained by Student’s t test, comparing the drop in 111 origins from WT to sir2 with that from WT to sir2 fun30 was highly significant (<<10 –16 ).

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