Effects of Tocotrienol on Cardiovascular Risk Markers in Patients With Chronic Kidney Disease: A Randomized Controlled Trial.

There was no effect on MDA levels (Cohen's d = 0.00; 95% CI: −0.95 to 0.95), but there was a substantial effect size that showed a trend toward a decrease in IL-6 (Cohen's d = −0.95; 95% CI: −1.95 to 0.05) and TNF- α (Cohen's d = −0.53; 95% CI: −1.50 to 0.44), whereas NRF2 and NF- κ B showed modest or negligible effect sizes (Cohen's d = −0.21; 95% CI: −1.17 to 0.74 and Cohen's d = −0.12; 95% CI: −1.07 to 0.84, respectively).

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