Polygenic risk scores for atrial fibrillation and heart failure and the risk of stroke and dementia.

Brain Commun · 2025 · PMC11748287 · PMID 39839839

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0.0930

closest p · 1.9× alpha

0.0930

boldest claim

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showed a trendP = 0.093so close (0.05 < p ≤ 0.1)

Higher AF-PRS, as a continuous variable ( Table 2 ), showed a trend toward an association with increased dementia risk at the 5 × 10 −8 (hazard ratio (HR) 1.11, 95% CI 0.98–1.26, P = 0.093), 1 × 10 −5 (HR 1.12, 95% CI 0.99–1.27, P = 0.071) and 1 × 10 −3 (HR 1.12, 95% CI 0.99–1.28, P = 0.071) thresholds.

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