Comprehensive analysis of H3K27me3 LOCKs under different DNA methylation contexts reveal epigenetic redistribution in tumorigenesis.

Epigenetics Chromatin · 2025 · PMC11748335 · PMID 39833880

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did not reach statistical significanceno p-value reported

Similar to the patterns observed in Roadmap samples, both normal and tumor cell lines showed a lower gene expression in long LOCKs within S-PMDs, although this did not reach statistical significance in the normal cell lines.

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