Pan-tumor analysis to investigate the obesity paradox in immune checkpoint blockade.

J Immunother Cancer · 2025 · PMC11748946 · PMID 39832896

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showed a trendp=0.05actually significant

IL-8 remained a significant predictor of OS in multivariable analysis adjusting for age, cancer group, gender, and race for OS (HR: 0.19 (95% CI: 0.05 to 0.70), p=0.01), as well as when adding obesity to the analysis (HR: 0.25 (95% CI: 0.07 to 0.94), p=0.04), though it showed a trend toward significance in multivariable analysis for PFS (HR: 0.55 (0.30–1.00), p=0.05).

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a trend toward significancep=0.05actually significant

Obesity remained a significant predictor in univariate analysis of PFS (HR: 0.44 (95% CI: 0.24 to 0.81), p=0.01) and OS (HR: 0.24 (95% CI: 0.07 to 0.80), p=0.02), with a trend toward significance in multivariable analysis of PFS (HR: 0.52 (95% CI: 0.27 to 1.00), p=0.05) and OS (HR: 0.28 (95% CI: 0.08 to 0.99), p=0.05).

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