Unbiased kidney-centric molecular categorization of chronic kidney disease as a step towards precision medicine.

As an overall trend, CKD-Gold–enriched genes showed a strong positive correlation with IFTA, whereas the CKD-Olive–enriched genes were strongly negatively correlated with IFTA, and genes enriched in the CKD-Plum and CKD-Blue molecular categories did not show significant associations with IFTA ( Figure 5d ; Supplementary Table S4 ).

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With directionality consistent with the hard endpoint prediction, the eGFR slopes showed a trend for greater annual loss of kidney function in the CKD-Gold category ( Figure 5b ).

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