Genetic factors shaping the plasma lipidome and the relations to cardiometabolic risk in children and adolescents.

1SMR analysis identified four nominally significant associations, including genetically predicted Cer(d39:1) with higher levels of ALT (β = 0.39; 95% CI = 0.11, 0.66; P = 0.0054), and AST (β = 0.32; 95% CI = 0.03, 0.60; P = 0.028), SM(d33:1) with higher HbA1c (β = 0.39; 95% CI = 0.12, 0.65; P = 0.0042), and PC(40:8) with lower bilirubin (β = −0.28; 95% CI = −0.55, −0.01; P = 0.044) ( Fig. 4 a, Supplementary Table S11 ).

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