RNAi-based ALOX15B silencing augments keratinocyte inflammation in vitro via EGFR/STAT1/JAK1 signalling.

Cell Death Dis · 2025 · PMC11754432 · PMID 39843435

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AA metabolite 15-HETE was significantly reduced and eicosapentaenoic acid (EPA)-derived 15-hydroxyeicosapentaenoic acid (HEPE) showed a trend towards lower concentrations after transfection with ALOX15B siRNA (Fig. 1F ).

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