Chlorpyrifos Acts as a Positive Modulator and an Agonist of <i>N</i>-Methyl-d-Aspartate (NMDA) Receptors: A Novel Mechanism of Chlorpyrifos-Induced Neurotoxicity.

Co-application of 10 μM CPF with 0.1 to 1000 μM NMDA reduced the NMDA EC 50 from 57.9 μM (95% CI 30.0–98.8) to 32.9 μM (95% CI 16.8–64.2) for GluN1-1a/GluN2A ( Figure 4 A) and from 70.0 μM (95% CI 39.9–111) to 35.5 μM (95% CI 20.7–59.3) for GluN1-1a/GluN2B ( Figure 4 B), although these reductions did not reach statistical significance ( p = 0.255 and 0.075, respectively).

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