Dose-dependent association of hyperoxia and decreased favorable outcomes in mechanically ventilated patients with traumatic brain injury, a retrospective cohort study.

Modeling time-weighted mean PaO 2 as a continuous parameter in logistic regression models with restricted cubic splines, a U-shaped relationship between PaO 2 and in-hospital mortality as well as neurological outcome at three to six months was observed, but did not reach statistical significance, neither in the univariate or multivariable analyses (supplement figures S2– S5).

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