However, surveillance studies have since described an increasing trend in metronidazole minimum inhibitory concentration (MIC) values for common C. difficile strains, which may contribute to the increasing number of metronidazole-associated treatment failures observed over the past decade [ 16 , 17 ].
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The sentences
In a meta-analysis, the use of probiotics for secondary prevention did not reach statistical significance to make a firm conclusion [ 86 ].