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In Vitro Evaluation of the Safety and Efficacy of <i>Cibisatamab</i> Using Adult Stem Cell-Derived Organoids and Colorectal Cancer Spheroids.

Cancers (Basel) · 2025 · PMC11763756 · PMID 39858076

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a clear trendno p-value reported
When directly comparing the cytotoxic effects of Cibisatamab across cancer spheroids and healthy organoids, we observed a clear trend of specific lysis in CEA high MKN-45 cancer spheroids and rectal organoids with intermediate CEA expression, while sparing DLD-1 spheroids and small intestinal organoids with lower CEA levels.

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