Non-Linear Effects of Acute Sleep Deprivation on Spatial Working Memory: Cognitive Depletion and Neural Compensation.

However, with the duration of deprivation extending to 24 h, the amplitude of the P2 component exhibited a highly significant reduction compared to baseline levels ( p < 0.001), indicating a substantial impact of prolonged sleep loss on early stages of information processing in the brain.

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Among these, the N2 trend was statistically significant and the P2 trend was marginally significant, whereas the P3 effect did not reach statistical significance.

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When mice experienced six hours of sleep deprivation, they exhibited a decline in spatial working memory function that did not reach statistical significance.

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