Targeting EP2 Receptor Improves Muscle and Bone Health in Dystrophin<sup>-/-</sup>/Utrophin<sup>-/-</sup> Double-Knockout Mice.

Cells · 2025 · PMC11763967 · PMID 39851544

Europe PMC DOI

hedged sentences

0.0835

closest p · 1.7× alpha

0.1461

boldest claim

The sentences

an increasing trendp = 0.0835so close (0.05 < p ≤ 0.1)

Cyclooxygenase 1 (Cox-1) mRNA expression in the thigh muscle of Mdx mice showed no significant change compared to WT mice but demonstrated an increasing trend in DKO-Hom mice ( p = 0.0835) ( Figure 1 C).

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a decreasing trendp = 0.1163not close (p > 0.1)

Total femur muscle HO volume (BV) showed a decreasing trend ( p = 0.1163) in PF04418948-treated versus vehicle-treated muscle ( Figure 4 F).

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showed a trendp = 0.1461not close (p > 0.1)

Immunohistochemistry staining of OSX for osteoprogenitor cells showed a trend of increasing OSX + cells ( p = 0.1461) in the PF04418948-treated group compared to the vehicle-treated group ( Figure 9 C,D).

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