Utility of Polygenic Risk Scores (PRSs) in Predicting Pancreatic Cancer: A Systematic Review and Meta-Analysis of Common-Variant and Mixed Scores with Insights into Rare Variant Analysis.

Although there was a modest increase in the average OR when clinical risk factors were incorporated, the comparison between the two groups did not reach statistical significance ( p = 0.15), and both subgroups showed considerable heterogeneity ( Figure 3 ).

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When analyzing AUC metrics, the number of SNPs in the PRS showed no significant association with the AUC, though larger PRS models suggested a positive trend.

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