Mendelian Randomization Study on hs-CRP and Dyslipidemia in Koreans: Identification of Novel SNP rs76400217.

Int J Mol Sci · 2025 · PMC11764716 · PMID 39859220

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.2670

boldest claim

The sentences

highly significantp < 0.001actually significant

After adjusting for age and sex (Model 2), the OR slightly increased to 2.11 (95% CI: 1.83–2.43), and the association remained highly significant ( p < 0.001).

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did not reach statistical significancep = 0.267not close (p > 0.1)

However, despite the effectiveness of rs76400217 as an IV, the association between hs-CRP concentrations and dyslipidemia did not reach statistical significance in any of the models, with odds ratios (ORs) of 1.44 ( p = 0.267), 1.50 ( p = 0.240), 1.51 ( p = 0.228), 1.48 ( p = 0.277), 1.49 ( p = 0.264), and 1.52 ( p = 0.236).

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