Modified human mesenchymal stromal/stem cells restore cortical excitability after focal ischemic stroke in rats.

Mol Ther · 2025 · PMC11764858 · PMID 39668560

Europe PMC DOI

hedged sentences

0.0940

closest p · 1.9× alpha

0.0960

boldest claim

The sentences

a slight trendp = 0.094so close (0.05 < p ≤ 0.1)

Stroke also significantly reduced the midline thickness of the corpus callosum, and hMSC-SB623 cell treatment showed a slight trend toward reversing this effect ( p = 0.094) ( Figure 7 D).

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showed a trendp = 0.096so close (0.05 < p ≤ 0.1)

hMSC-SB623 cell treatment significantly increased the density of proliferating RECA + ki67 + endothelial cells in the ipsilesional cortex and corpus callosum as a whole, and showed a trend ( p = 0.096) for a reduction of the density of RECA1 + ki67 + cells in the ipsilesional internal capsule ( Figure S10 D).

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highly significantno p-value reported

This analysis showed a highly significant negative correlation between genes significantly changed by stroke and those significantly changed by hMSC-SB623 cell treatment on day 3 as well as on day 7 after treatment ( Figure 8 E).

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