showed a trendp -value = 0.05
As expected, the Schmidt’s score was markedly increased in both AP models, and in Cer-AP it was reduced in mice treated with APOA1 and FGF21 LNP-mRNAs, whereas in the EtOH/POA-AP model APOA1 LNP-mRNA significantly reduced this score, and FGF21 and APOA1-FGF21 LNP-mRNAs showed a trend toward a therapeutic effect ( p -value = 0.05) (Figs. 5 B and 6 B).