Progesterone induces meiosis through two obligate co-receptors with PLA2 activity.

However, because pristimerin showed a trend toward inhibition at the highest concentration, we tested its effect at low P4 concentration where it inhibited oocyte maturation but required a concentration of 10 –5 M ( Figure 3—figure supplement 1C ), which is two orders of magnitude higher than its documented IC 50 in other systems ( Mannowetz et al., 2017 ).

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