Genetically predicted brain cortical structure mediates the causality between insulin resistance and cognitive impairment.

Front Endocrinol (Lausanne) · 2024 · PMC11774689 · PMID 39882263

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nominally significantno p-value reported

P-values between 0.05 and the specified threshold were considered nominally significant. 2.4.2 Mediation analysis The two-step univariable mediation MR analysis was implemented to investigate whether brain cortical structure mediates the causal pathway from insulin resistance to cognition outcome.

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borderline significantno p-value reported

The causal effects of HOMA-IR on SA of both precentral (IVW: beta=-161.91, 95%CI=-272.50 to -51.32, p =0.004) and insula (IVW: beta=84.15, 95%CI=26.30 to 142.00, p =0.004) turned borderline significant after Bonferroni adjustment.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.