Higher Long-Term Visit-to-Visit Blood Pressure Variability Is Associated With Severe Cerebral Small Vessel Disease in the General Population.

Only high SBP variability was significantly associated with an increased risk of moderate cSVD burden (OR = 4.87, 95% CI: 1.14–20.83, p = 0.033), while its association with severe cSVD burden approached significance (OR = 3.87, 95% CI: 0.90–16.74, p = 0.070). 3.4 Associations Between BPV and Burden of cSVD/Different Markers of cSVD by Gender and Hypertension Status The association between BPV and cSVD burden or different markers of cSVD was consistent both in males and females (Figure 4 ).

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