A network-based analysis anticipates time to recovery from major depression revealing a plasticity by context interplay.

Additionally, we explored network connectivity strength over time and observed that, across all patient groups, it showed a trend toward a decrease prior to achieving clinical response, except for the group that responded in week 4, which consistently exhibited weak connectivity (Figure S6 ).

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Furthermore, we highlight the pivotal role of the interplay between plasticity and context, as the relationship between connectivity strength and time to recovery is highly significant in favorable but not in unfavorable conditions: the experience of a good life context appears to promote mental wellbeing only when combined with high plasticity.

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