Explorative Study of Modulatory Effects of Notochordal Cell-Derived Extracellular Vesicles on the IL-1β-Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants.

JOR Spine · 2025 · PMC11775941 · PMID 39881783

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did not reach statistical significanceno p-value reported

The number of particles in one donor (#4) was visibly lower, but this did not reach statistical significance.

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failed to reach significanceno p-value reported

The release of PGE2 in explants treated with NC‐EVs + IL‐1β decreased by 50‐fold compared to IL‐1β treatment alone, although this failed to reach significance (Figure 8A ).

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