P2X7R antagonism suppresses long-lasting brain hyperexcitability following traumatic brain injury in mice.

When treatment was delayed to day 7 post-CCI (treatment window 2; Figure 3 F), mice subjected to CCI and treated with JNJ-54175446 had less severe behavior seizures when compared to mice subjected to CCI and treated with vehicle, although this reduction in seizures did not reach statistical significance (Figure 3 G).

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