Associations between plasma metabolism-associated proteins and future development of giant cell arteritis: results from a prospective study.

For meteorin-like protein (Metrnl), the highest impact on the risk of GCA was observed in those patients sampled closest to diagnosis, with a decreasing trend with longer time to GCA ( P = 0.03).

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However, in the stratified analysis there was a significant trend ( P = 0.030), with higher ORs in those sampled closer to GCA diagnosis, i.e. quartile 1 [OR (per S.D.) 2.40; 95% CI 0.98–5.85, P = 0.055] and quartile 2 [8.50–11.96 years before diagnosis; OR (per S.D.) 3.13; 95% CI 0.92–10.63, P = 0.067], respectively, compared with those sampled with a longer duration to diagnosis.

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In the analysis stratified by time from screening to diagnosis, the lowest OR was found in the quartile sampled closer to GCA diagnosis (OR 0.29; 95% CI 0.06–1.39), with an increasing trend by quartile three.

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