Dietary intervention of prebiotic partially hydrolyzed guar gum improves skin viscoelasticity, stratum corneum hydration, and reduction of trans-epidermal water loss: a randomized, double-blind, and placebo-controlled clinical study in healthy humans.

In this 12-week, randomized, double-blind, crossover, placebo-controlled study, supplementing once daily with 5 ‍g of a PHGG prebiotic fiber (Sunfiber ® ) containing nearly 4 ‍g soluble dietary fiber showed an increasing trend in skin viscoelastic properties and SCH, and a significant decrease in TEWL from baseline when compared to placebo.

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In the placebo group, the SE correlation coefficients (i.e., R0, R2, R5, R6, and R7) were inversely correlated with skin SCH and did not reach statistical significance.

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In terms of clinical relevance, the p values of ≤0.05 were deemed statistically significant, while ≤0.10 was viewed as trending toward significance.

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