Histone methyltransferase KMT2A promotes pulmonary fibrogenesis via targeting pro-fibrotic factor PU.1 in fibroblasts.

gned a Col1a2‐specific promoter to achieve higher efficiency of infection in fibroblasts (Figure 2A,B ).Western blotting results indicated that the expression of Collagen I was significantly down‐regulated in the lungs of mice treated with AAV6‐shKmt2a+BLM, while α‐SMA showed a decreasing trend but did not reach statistical significance (Figure 2G,H ).

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hRNA sequences and designed a Col1a2‐specific promoter to achieve higher efficiency of infection in fibroblasts (Figure 2A,B ).Western blotting results indicated that the expression of Collagen I was significantly down‐regulated in the lungs of mice treated with AAV6‐shKmt2a+BLM, while α‐SMA showed a decreasing trend but did not reach statistical significance (Figure 2G,H ).

also in 47,180 other papers