Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers.

Genes that had increasing expression among pathologic types satisfied the following two criteria: Nominally significant difference from normal: (B1) P A A H < 0.05 and P A I S < 0.05 and P M I A _ n o n I n v < 0.05 and P M I A _ I n v < 0.05 Increased expression from normal to AAH, to AIS, and to MIA (MIA_ nonInv and/or MIA_Inv): (B2) ( β M I A _ I n v and / or β M I A _ n o n I n v ) > β A I S > β A A H > 0 in which P is the P value and β is the β-coefficient in the linear model for a gene.

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