CD155 promotes the progression of colorectal cancer by restraining CD8⁺ T cells via the PI3K/AKT/NF-κB pathway.

Although CD155 overexpression slightly promoted CT26 proliferation, migration, and invasion compared with the control, the difference did not reach statistical significance, and CD155 did not enhance tumor growth in BALB/c-nude mice, which lack a thymus.

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