Distal protein-protein interactions contribute to nirmatrelvir resistance.

Nat Commun · 2025 · PMC11787374 · PMID 39893201

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possibly not significantno p-value reported

The effect of the T21I mutation on the protein-protein interactions at this interface may be difficult to predict and possibly not significant due to its peripheral location.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.