The Cdk inhibitor dinaciclib as a promising anti-tumorigenic agent in biliary tract cancer.

A clear trend was determined for OCUG-1 cells, concentrations over 25 nM led to a weak reduction of cell viability after 24 h, but viability was stronger reduced after 48 and 72 h incubation with dinaciclib.

also in 19,460 other papers

Cdk1 and Cdk2 showed the highest expression in EGI-1, MMNK-1 and NOZ and CCC-5, MMNK-1 and NOZ, respectively ( Figure 2b ). While the results of IHC and immunoblotting were not identical, immunoblot correlation analysis of all cell lines revealed a highly significant positive correlation between Cdk5 protein expression and IC 50 values of dinaciclib ( Figure 3a correlation plot Figure 3b ).

also in 132,142 other papers