Brain Proteome Profiling Reveals Common and Divergent Signatures in Parkinson's Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy.

Mol Neurobiol · 2025 · PMC11790761 · PMID 39164482

Europe PMC DOI

hedged sentences

0.0003

closest p · 0.0× alpha

0.0570

boldest claim

The sentences

highly significantp = 0.0003actually significant

Compared to controls, PD exhibited a significant decrease in neuronal estimates ( p = 0.017), a decrease in astrocyte estimates ( p = 0.01), and a highly significant decrease for endothelial cell estimates ( p = 0.0003).

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showed a trendp = 0.057so close (0.05 < p ≤ 0.1)

MSA samples showed a trend for a decrease in excitatory neuronal estimates in layer 4 (L4, p = 0.057) and a significant decrease for excitatory neurons in layers 5 and 6 (L5/6, p = 0.0009).

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