Glucokinase activator improves glucose tolerance and induces hepatic lipid accumulation in mice with diet-induced obesity.

Liver Res · 2023 · PMC11791924 · PMID 39958949

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a clear trendno p-value reported

However, a clear trend of increased plasma TG, as well as ALT/AST activity after 24 weeks of GKA treatment, 13 suggests its potential risk on liver function, and liver function status should be considered for GKA prescription.

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