Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD.

Treatment with HPCD was associated with more efficient cholesterol efflux, as evidenced by increased trends of small HDL particle formation in cerebrospinal fluid (CSF) and plasma, although these changes did not reach statistical significance due to the small sample size (Supplementary Fig. 7 D-F).

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