The administration of ghrelin in healthy subjects, besides metabolic effects and hunger induction, was reported to elevate mood [ 32 ] and to increase plasma cortisol levels [ 33 ], while male but not female MDD patients who received acute ghrelin administration showed a trend for improvement of depressive symptoms including sleep disturbances [ 34 ].
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Ghrelin, Neuroinflammation, Oxidative Stress, and Mood Disorders: What Are the Connections?
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