Barely Significant
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A CADASIL NOTCH3 mutation leads to clonal hematopoiesis and expansion of Dnmt3a-R878H hematopoietic clones.

Leukemia · 2025 · PMC11794143 · PMID 39537978

Europe PMCDOI
1
hedged sentence
0.1000
closest p · 2.0× alpha
0.1000
boldest claim

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did not reach statistical significancep < 0.1so close (0.05 < p ≤ 0.1)
The frequency of HSCs trended up but did not reach statistical significance ( p < 0.1) within GFP + NOTCH3 C455R/+ HSPCs compared to the frequency of HSC within GFP − NOTCH3 C455R/+ HSPC (Fig. 2D ).

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