Distinct sex differences in ethanol consumption and operant self-administration in C57BL/6J mice with uniform regulation by glutamate AMPAR activity.

Results showed that female mice exhibited a strong trend for an increase in PR breakpoint [ t (14) = 1.63, p = 0.0627; Figure 4H ] as well as corresponding significant increases in PR session duration [ t (14) = 2.1, p = 0.027] and number of headpokes per session [ t (12) = 2.02, p = 0.033; Figures 4I , J ].

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However, linear regression revealed a significant positive slope for ethanol-reinforced responding in female mice [Y = 1.172X + 65.80, F (1,238) = 15.24, p < 0.0001], indicating an increasing trend.

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