Progression of brain injuries associated with methotrexate chemotherapy in childhood acute lymphoblastic leukemia.

The poorer performance of patients at year 1 but not at baseline, in the absence of significant change, is likely attributable to (a) poorer performance in patients at baseline that did not reach statistical significance, or (b) performance either increased nonsignificantly for healthy controls or decreased nonsignificantly for patients, especially on the digit span and matrix reasoning tasks.

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