Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology.

4 C) demonstrated a slight trend towards dimerization following treatment with SAD SiNPs, indicating some degree of oxidation, but mitochondrial PRX-3 was found to respond more strongly (Fig. 4 D) with a 16-fold increase in dimerization relative to control.

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Although these pathways did not reach statistical significance by this timepoint, this change may be indicative of some of the protective pathways contributing to cell survival — cell cycle regulation is essential to allow cells time to repair damage prior to division [ 71 ].

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