The anti-circumsporozoite antibody response to repeated, seasonal booster doses of the malaria vaccine RTS,S/AS01<sub>E</sub>.

The sustained protection achieved over a five-year period was accompanied by increases in anti-CSP antibody titre following each annual booster dose, although the increase in titre post vaccination was substantially less than that seen after the three priming or first booster dose and showed a trend towards a lower response after each repeated booster dose.

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