Characterization of focused ultrasound blood-brain barrier disruption effect on inflammation as a function of treatment parameters.

Biomed Pharmacother · 2025 · PMC11803570 · PMID 39719739

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.0001

boldest claim

The sentences

highly significantp < 0.0001actually significant

Two-way ANOVA analysis of the hemorrhage area for the FUS Intensity groups indicates a highly significant main effect of FUS intensity (p < 0.0001).

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did not reach statistical significanceno p-value reported

Iba-1, NLRP3, TNF, IL1B, IL6, IL10, ICAM, MMP9 and iNOS all displayed the highest upregulation for the highest microbubble-dose at 24 h post-FUS, albeit the main effect of microbubble dose did not reach statistical significance.

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