Lactoferrin alleviates the adverse effects of early-life inflammation on depression in adults by regulating the activation of microglia.

Mol Med · 2025 · PMC11803964 · PMID 39920579

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

an increasing trendp = 0.08so close (0.05 < p ≤ 0.1)

However, in the ko-wt group, the proportion of injured neurons in the hippocampal DG region showed an increasing trend ( p = 0.08) 12 h after LPS injection.

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did not reach statistical significanceno p-value reported

Consistent with our study, LF enhanced the expression of IL-1β and reduced the production of TNF-α in the spleen of piglets, although the difference did not reach statistical significance (Li 2014 ).

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