Single-chain variable fragment affinity tuning can optimize anti-AML CAR-NK cell functionality.

J Immunother Cancer · 2025 · PMC11804205 · PMID 39915004

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did not reach statistical significanceno p-value reported

Co-culture with CD123 + target cells stimulated higher IFNγ secretion from CAR-modified NK cells compared with untransduced NK cells, although these differences did not reach statistical significance and affinity differences were not noted ( online supplemental figure 7D,E ).

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