Longitudinal characterization reveals behavioral impairments in aged APP knock in mouse models.

Sci Rep · 2025 · PMC11805898 · PMID 39920176

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0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

a clear trendp = 0.054so close (0.05 < p ≤ 0.1)

While 2–3 month APP SAA mice showed a clear trend towards a novelty preference on the OLT ( p = 0.054), 16 month APP SAA mice had a novelty preference score that was no different than chance levels (despite spending similar time exploring the objects, Supplementary Fig, S2 a), suggesting that they were no longer able to remember which object had been moved (Fig. 2 a).

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