Reliability of in vitro data for the mechanistic prediction of brain extracellular fluid pharmacokinetics of P-glycoprotein substrates in vivo; are we scaling correctly?

Moreover, a comparison of the PEs of the continuous infusion predictions made using the low in vitro P-gp expression for references that reported transport values for multiple drugs, showed a trend of PE paliperidone > PE risperidone > PE verapamil > PE quinidine (supplementary Fig. 3).

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